T or F: RMS rarely spread by hematogenous routes.

1.   ?    True
2.   ?    False

What are peak ages at diagnosis of rhabdomyosarcoma?

1.   ?    Under 2 years
2.   ?    2 - 5 years
3.   ?    6 - 9 years
4.   ?    10 - 18 years

True or false: just like neuroblastoma, infants under 1 year of age with rhabdomyosarcoma have improved survival?

1.   ?    True
2.   ?    False

What patients are NOT at increased risk for rhabdomyosarcoma?

1.   ?    Basal cell nevus syndrome
2.   ?    Medulloblastoma in 1st degree relative
3.   ?    Neurofibromatosis
4.   ?    Siblings with brain cancer or adrenocortical tumors

Female relatives of children with rhabdomyosarcoma have an increased incidence of what?

1.   ?    Breast Cancer
2.   ?    Thyroid (follicular) cancer
3.   ?    Rhabdomyosarcoma

T or F: Most RMS patients are Clinical group 1 and 2?

1.   ?    True
2.   ?    False

What is overall 5 year survival in RMS?

1.   ?    10 percent
2.   ?    25 percent
3.   ?    45 percent
4.   ?    65 percent

What site has the best survival in rhabdomyosarcoma?

1.   ?    Head and Neck
2.   ?    Bile duct
3.   ?    Chest wall
4.   ?    Orbit

Which site is NOT one of the poor prognosis sites?

1.   ?    Chest wall
2.   ?    Buttocks
3.   ?    Non-genitourinary pelvic
4.   ?    Vagina and vulva

Which is NOT one of the 3 primary factors determining the prognosis in rhabdomyosarcoma?

1.   ?    Age
2.   ?    Site
3.   ?    Stage
4.   ?    Histology

Lymph nodes are more likely to be positive in rhabdomyosarcoma in all of the following conditions EXCEPT?

1.   ?    Unfavorable histology
2.   ?    Extremity, retroperitoneal, or trunk lesions
3.   ?    Size greater than 5 cm
4.   ?    Aneuploidy

Which is the most commonly seen histologic variant of RMS?

1.   ?    Botyroid
2.   ?    Alveolar
3.   ?    Embryonal
4.   ?    Pleomorphic

Which histologic variant has the worst prognosis?

1.   ?    Botyroid
2.   ?    Alveolar
3.   ?    Embryonal
4.   ?    Pleomorphic

T or F: Alveolar RMS has the highest rate of positive lymph nodes, positive bone marrow, local recurrence and distant spread?

1.   ?    True
2.   ?    False

In what percent of soft tissue rhabdomyosarcomas can the precise histologic subtype NOT be identified?

1.   ?    50 percent
2.   ?    25 - 30 percent
3.   ?    10 - 15 percent
4.   ?    Less than 5 percent

What chromosomal abnormality is often found in alveolar rhabdomyosarcoma?

1.   ?    2 to 13 translocation
2.   ?    Trisomy 15
3.   ?    5 to 9 translocation
4.   ?    11p deletion

Which is NOT one of the most common sites of alveolar rhabdomyosarcoma?

1.   ?    Extremity
2.   ?    Trunk
3.   ?    Orbit
4.   ?    Perianal

T or F: Stage 1 RMS patients with favorable histology do NOT receive chemotherapy?

1.   ?    True
2.   ?    False

The type and duration of chemotherapy in rhabdomyosarcoma depends on all EXCEPT what?

1.   ?    Site
2.   ?    Stage - TMN
3.   ?    Age
4.   ?    Histology

Which is NOT true regarding the treatment of rhabdomyosarcoma?

1.   ?    Primary re-excision for microscopically positive disease
2.   ?    Stage 3 requires second look > 6 months after treatment
3.   ?    Primary en bloc resection for involved viscera
4.   ?    Chemotherapy in stage 1 for 1 year
5.   ?    Chemotherapy in stage 2 and 3 for 18 months

What is the mortality from the treatment of rhabdomyosarcoma (mostly secondary to chemotherapy complications)?

1.   ?    2 - 3 percent
2.   ?    5 - 10 percent
3.   ?    15 percent

What is the mean age of vaginal rhabdomyosarcoma?

1.   ?    About 1 year of age
2.   ?    About 2 years of age
3.   ?    5 years of age
4.   ?    10 - 15 years of age

Is rectal extension of vaginal rhabdomyosarcoma common?

1.   ?    Yes
2.   ?    No

True or false: most vaginal rhabdomyosarcomas require pelvic exenteration?

1.   ?    True
2.   ?    False

Most vaginal rhabdomyosarcoma is of what histologic subtype?

1.   ?    Alveolar
2.   ?    Pleomorphic
3.   ?    Embryonal
4.   ?    Anaplastic

True or false: most VULVAR rhabdomyosarcomas can be treated by local excision and chemotherapy?

1.   ?    True
2.   ?    False

What percent of uterine rhabdomyosarcomas are embryonal?

1.   ?    25 percent
2.   ?    50 percent
3.   ?    80 percent

True or false: uterine rhabdomyosarcoma does not have nearly as good prognosis as vaginal rhabdomyosarcoma?

1.   ?    True
2.   ?    False

What percent of rhabdomyosarcomas of the bladder are located in the dome?

1.   ?    10 percent
2.   ?    25 percent
3.   ?    50 percent
4.   ?    75 percent

Which type of rhabdomyosarcomas have greatest likelihood of positive lymph node involvement by CT - Bladder or prostate?

1.   ?    Bladder RMS
2.   ?    Prostate RMS

What is the current treatment of rhabdomyosarcoma located in the bladder, but not in the dome?

1.   ?    Initial pelvic exenteration
2.   ?    Intial radiation and then resection
3.   ?    Aggressive chemo, extensive local resection, then radiation + chemo
4.   ?    Nigra protocol, followed by resection

What are the current bladder salvage and survival rates in bladder rhabdomyosarcoma?

1.   ?    30% salvage, 50% survival
2.   ?    20% salvage, 75% survival
3.   ?    60% salvage, 80% survival
4.   ?    80% salvage, 90% susvival

How does paratesticular rhabdomyosarcoma spread?

1.   ?    Direct extension
2.   ?    Lymphatics
3.   ?    Hematogenous

Paratesticular RMS has a (good or bad) prognosis?

1.   ?    Good outcome
2.   ?    Bad outcome

Is retroperitoneal lymph node dissection performed for paratesticular rhabdomyosarcoma?

1.   ?    Yes
2.   ?    No

Extremity RMS is more common in upper than lower extremity - T or F?

1.   ?    True
2.   ?    False

What percentage of rhabdomyosarcomas in an extremity have lymph node involvement?

1.   ?    Less than 5%
2.   ?    10 to 15 percent
3.   ?    20 to 25 percent
4.   ?    35 to 50 percent

What is the most common histology in extermity RMS?

1.   ?    Alveolar
2.   ?    Pleomorphic
3.   ?    Embryonal
4.   ?    Anaplastic

Currently what percent of extremity rhabdomyosarcomas can be treated without any amputation?

1.   ?    25 percent
2.   ?    50 percent
3.   ?    75 percent
4.   ?    95 percent

True or false: biopsy and primary aggressive chemotherapy is the standard treatment for extremity rhabdomyosarcoma?

1.   ?    True
2.   ?    False

What is the third most common head and neck tumor in children

1.   ?    Hodgkin's Lymphoma
2.   ?    non-Hodgkin's Lymphoma
3.   ?    Rhabdomyosarcoma

Which of the 3 head and neck rhabdomyosarcomas has the best prognosis?

1.   ?    Orbit
2.   ?    Nonparameningeal
3.   ?    Parameningeal

T or F: Many (31%) of parameningeal rhabdomyosarcomas are classified as group 3 because their location makes it very difficult to completely resect?

1.   ?    True
2.   ?    False

The diagnosis of what should be suspected in a child with a painful cheek mass and trismus?

1.   ?    Rhabdomyosarcoma
2.   ?    Hodgkin's disease
3.   ?    Neuroblastoma

What is the approximate incidence of bony orbital hypoplasia and facial asymmetry in orbital RMS?

1.   ?    10 percent
2.   ?    20 percent
3.   ?    50 percent
4.   ?    75 percent

T or F: nonparameningeal head and neck rhabdomyosarcomas usualy require cervical lymph node dissection?

1.   ?    True
2.   ?    False

T or F: children with base of the skull involvement without CSF involvement do not get whole brain irradiation.

1.   ?    True
2.   ?    False

Most rhabdomyosarcomas of the bile duct have widespread disease at diagnosis, and the histology is usually what?

1.   ?    Alveolar
2.   ?    Pleomorphic
3.   ?    Embryonal
4.   ?    Anaplastic

What is the most common histology in the rare (2% of RMS) cases of perianal or perineal RMS?

1.   ?    Alveolar
2.   ?    Pleomorphic
3.   ?    Embryonal
4.   ?    Anaplastic

What is the most common histology in chest wall RMS?

1.   ?    Alveolar
2.   ?    Pleomorphic
3.   ?    Embryonal
4.   ?    Anaplastic

What is the five-year survival for rhabdomyosarcoma (overall) with metastatic disease?

1.   ?    15 percent
2.   ?    30 to 40 percent
3.   ?    50 to 60 percent
4.   ?    80 percent